The Serotonin Receptor Antagonists Nan-190, Methiothepin, Methysergide, Mianserin or Ondansetron Protect against Methamphetamine-induced Hyperthermia in Mice

The effect of some serotonin receptor antagonists was investigated on the body temperature of male mice. These antagonists produced significant reductions of body temperature in methamphetamine-induced hyperthermic male mice. Thus, the hyperthermia induced by methamphetaminc (11 ~tmol/kg,i.p.) was antagonized by the previous i.p. administration of 1.06 gmol/kg NAN-190 (5-HTIA receptor antagonist), 22.1 ftmol/kg methiothepin (5-l-lTi~1i0 receptor antagonist), 2.13 ptrnol/kg methysergide (5-HT 2A/2B receptor antagonist), 3.3 ~.tmo]/kg mianserin (5-HT2c and u2 adrenoceptor antagonist) or 0.003 ~rmo1/kg ondansetron (5-HT3 receptor antagonist). The present results indicate that central serotonin receptors may be involved in the hyperthermic effect of methamphetamine.